5% solution of benzoyl alcohol for the treatment of head lice in people 6 months of age and older. In all other short‐term inhalation studies with exposure times between 4 and 6 hours, no mortality was observed; the investigated concentrations were between 61 ml/m3 (274 mg/m3) and 4178 mg/m3. In a study carried out in accordance with OECD Test Guideline 405, benzyl alcohol is described as irritating in the eyes of rabbits (ECHA 2014). The TK+/‐ mutation test in mouse lymphoma cells with metabolic activation yielded a positive result, however at clearly cytotoxic concentrations, so that the effect can be attributed to the toxicity of benzyl alcohol and not to its mutagenic potential. : metabolic activation; n.i. (2014). This is apparently a thing now that people are writing exams from home. All available data for the genotoxicity of benzyl alcohol in vitro are summarized in Table 5 (see also The effect with the highest incidence was minimal mononuclear infiltrates in the lungs in 5 of 10 males from the high concentration group, but not in any animals of the control group. Use the link below to share a full-text version of this article with your friends and colleagues. One female patient, who had had dermatitis of the arms and legs for ten years and had undergone repeated topical antibiotic and corticoid treatment for her chronic leg eczema, reacted in the patch test to benzyl alcohol, several external agents and cosmetics containing benzyl alcohol as a preservative, and a number of other substances, including wool alcohol and neomycin (Curry and Warshaw 2005). Benzyl alcohol did not induce gene mutations in bacteria and mammalian cells. Benzyl alcohol is produced industrially from toluene via benzyl chloride, which is hydrolyzed: Mutagenic and antimutagenic activities of flavoring agents used in foodstuffs, https://doi.org/10.1002/3527600418.mb10051kske6318, supplement “Benzoic acid and alkali benzoates” 2017, http://echa.europa.eu/web/guest/information‐on‐chemicals, http://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022129s000_PharmR.pdf, http://www.dguv.de/en/data_bases/index.jsp, http://www.ifraorg.org/en‐us/search/s/NESIL_benzyl_alcohol, http://www.merckmillipore.com/DE/en/product/Benzyl‐alcohol,MDA_CHEM‐109626, http://www.merckmillipore.com/DE/de/product/Benzyl‐alcohol,MDA_CHEM‐109626, http://toxnet.nlm.nih.gov/cgi‐bin/sis/htmlgen?HSDB, http://www.inchem.org/documents/sids/sids/benzoates.pdf, n.c.: not calculable, as data are lacking, EMS: ethylmethane sulfonate; MMC: mitomycin C; mwh: multiple wing hair; PCE: polychromatic erythrocytes; SLRL: sex‐linked recessive lethal mutations; SMART: somatic mutation and recombination test. The induction of DNA strand breaks was tested using alkaline elution and an alkaline comet assay. Salts of benzoic acid are used as food preservatives. 2013). C 6 H 5 CH 2 Cl + H 2 O → C 6 H 5 CH 2 OH + HCl. Benzyl alcohol is metabolized into Benzoic Acid and interacts with glycine and is excreted in the human body as hippuric acid. This is assumed to be the result of lower glycine acyltransferase activity and a depletion in glycine (LeBel et al. In a valid 16‐day study, groups of 5 male and 5 female F344/N rats and B6C3F1 mice were given oral doses of benzyl alcohol of 0, 125, 250, 500, 1000 or 2000 mg/kg body weight and day for 12 days. Neither substance‐related effects nor gross‐pathological changes could be found in the animals that had inhaled 182, 357 or 781 mg benzyl alcohol/m3 (no further details; Katz and Fennikoh 1983). After conjugation with glycine, 80% is eliminated as hippuric acid and up to 20% as glucuronide (see Monograph No. In human liver microsomes, on the other hand, cytochrome P450 and not alcohol dehydrogenase has been described as the metabolizing enzyme of benzyl alcohol (Chapman et al. At the challenge, 2 and 3 of the 56 volunteers had 2+ or 1+ reactions; these were also reproducible in one of the volunteers in each case in a challenge repeated both on an occlusive and a semi‐occlusive basis. However, teratogenic effects were not investigated (OECD 2004). Benzyl alcohol + 4 KMnO 4 3 H 2 O + 4 MnO 2 + 2 H 2 O + KOH Potassium benzoate Potassium permanganate 3 Benzoic acid 3 OH O K O OH O HCl. In a 4‐week study carried out according to OECD Test Guideline 412, groups of 10 male and 10 female Sprague Dawley rats were exposed nose‐only to benzyl alcohol concentrations of 0, 41, 102, 290 or 1072 mg/m3 for 6 hours a day, on 5 days per week. In a study, groups of 4 rats were exposed by inhalation to benzyl alcohol concentrations of 0, 190, 334, 643 or 1119 mg/m3 for 6 hours a day, on 3 days. Repeated insult patch tests with benzyl alcohol preparations in a mixture of diethyl phthalate/ethanol (3:1) were carried out in groups of 46 to 110 volunteers. documentation “Benzylalkohol” 2006, available in German only), no MAK value could be established as data for the determination of a concentration without irritative effects after inhalation exposure were lacking.


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